Phenotype 1

Metabolic PMOS

Insulin-Resistant Pattern: the most common presentation

Elevated fasting insulinHigh testosteroneIrregular cyclesWeight-related

Phenotype 2

Adrenal PMOS

Stress-Driven Pattern: elevated DHEA-S, often normal insulin

Elevated DHEA-SStress-triggeredAnxiety & sleep disruptionOften lean

Phenotype 3

Inflammatory PMOS

Immune-Driven Pattern: gut barrier dysfunction as root cause

Elevated hs-CRPGut symptomsAutoimmune co-conditionsNormal insulin

Phenotype 4

Lean Neuroendocrine PMOS

Brain-Ovary Signaling Pattern: rapid GnRH pulses drive LH excess and ovarian androgens

Elevated LH:FSH ratioHigh AMHNormal BMIInsulin often normal

Bonus Phenotype

Post-Pill PMOS

Hypothalamic Recovery Pattern: HPO axis suppression post-OCP

Regular cycles pre-pillAnovulation post-OCPNutrient depletionNormal androgens

PMOS Phenotype Overview

Recalibrate PLLC